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Published: October 13, 2023

What Is the Success Rate of Euflexxa Injections?

Did you know that more or less painful osteoarthritis affects more than 500 million people worldwide? It is a very common chronic disease characterized by the feeling of discomfort in joints. Despite the fact that it cannot be fully cured, its signs might be substantially reduced by a number of methods, including hyaluronic acid injections.

One of the most well-known brands that produce these hyaluronic acid injections is Euflexxa. But how effective is it and what is its success rate? Check out this article to find the answers to all the questions you might have regarding Euflexxa injections. Let us discover the advancements of orthopedic medicine together!


Are you looking to assess the advantages and disadvantages of Euflexxa? Delve into our article, “Evaluating Pros and Cons of Euflexxa,” for insightful information that can guide you in making informed decisions about this treatment.

What Is Euflexxa?

Euflexxa is a brand of intra-articular injections used to address the feeling of ache caused by osteoarthritis of the knee. It is manufactured by a research-driven pharmaceutical company Ferring Pharmaceuticals, which involves numerous clinical trials (including open-label safety extension studies, randomized controlled trial investigations, and secondary outcome measures) and advantageous medical innovations in the production process.

While being created on the basis of a complex production process, Euflexxa is a medication characterized by its high-quality composition, strong efficacy, and durable results. By means of treating osteoarthritis cartilage, Euflexxa substantially reduces the knee pain of a patient and, therefore, provides him or her with an improved quality of life.


Euflexxa is a knee osteoarthritis treatment intended for professional use. Thus, only a certified healthcare provider is eligible to order Euflexxa online and administer it to a patient’s knee. Euflexxa is not intended for home use.

Senior man suffering from pain in his knee at home. concept of problems with joint like arthritis

What Is the Composition of Euflexxa?

The composition of Euflexxa is based on hyaluronic acid (also known as sodium hyaluronate). It is a highly purified synthetic substance that effectively compensates for the lack of natural hyaluronic acid in human joints. After being administered to the knees of a patient, hyaluronic acid substantially reduces their stiffness, takes care of inflammation, and returns the full range of motion to the treated leg.

It is also worth mentioning that hyaluronic acid in the composition of Euflexxa functions as a lubricant and shock absorber for the target knee. By doing so, it minimizes the symptoms related to osteoarthritis of the knee in a quick, effective, and durable way. Despite the fact that Euflexxa cannot help a patient to fully cure his or her knee osteoarthritis, it can substantially reduce its symptoms.


Contemporary orthopedic medicine offers a wide range of medications and supplements to address the symptoms of painful osteoarthritis. Apart from Euflexxa, you might also come across Crespine, Monovisc, Orthovisc, Synvisc, and a great number of other brands.

What Are the Indications for Euflexxa Injections?

The main indication for Euflexxa injections is knee joint pain caused by osteoarthritis. In most cases, about three injections of the medication might be required to take care of negative painful feelings and restore the mobility function of the affected knee. However, a patient might also feel substantial improvement in his or her condition even after the first injection of the medication.

It is also important to mention that therapy with the help of Euflexxa injections is usually prescribed to patients who have tried other non-invasive methods to minimize their osteoarthritis-related knee pain, starting from physical therapy and ending with the intake of simple analgesics (such as acetaminophen) which, however, led to no substantial improvements.


Despite the fact that Euflexxa is primarily indicated to take care of osteoarthritis-related pain in the knee joint, the treatment might also be used to address osteoarthritis-related pain in the hip, ankle, foot, shoulder, wrist, elbow, and the base of thumb joints.

What Are the Contraindications to Euflexxa Injections?

Euflexxa is a rescue medication for those patients who would like to avoid surgery and look for a way to reduce their osteoarthritis-related knee pain by means of restoring their knee cartilage. Despite its minimal invasiveness and high safety, the treatment is contraindicated to patients under any of the following circumstances:

  • Allergy to hyaluronic acid;
  • Knee infection;
  • Skin infection around the intended injection site;
  • Overall health problems (for instance, high blood pressure);
  • Chronic diseases.


Apart from the above-mentioned contraindications to the treatment, Euflexxa should also not be injected if a patient is pregnant or breastfeeding. If possible, it is preferable to postpone the therapy till a baby is born and breastfeeding is over.

What Are the Possible Side Effects After Euflexxa Injections?

Under normal circumstances, Euflexxa is a rescue medication with minimal adverse reactions. However, a patient might experience several side effects after undergoing the first, second, or third injection of the product. They are mild ache in the affected joint (including joint swelling), overall musculoskeletal pain, skin irritation around the injection site, nausea, and so on.

Luckily, the above-mentioned side effects do not usually carry any serious health risks. They tend to disappear in two to five days after the treatment without any medical supervision. Still, it is recommended that a patient informs a healthcare provider in case of having any of them after the Euflexxa treatment.


In rare cases, Euflexxa injections might lead to severe headaches, diarrhea, fatigue, high blood pressure, and other adverse reactions that should by no means be ignored. If these serious side effects occur, a patient has to contact a healthcare provider as soon as possible.

What Are the Expected Results of Euflexxa Injections?

Under normal circumstances, Euflexxa injections create instantly noticeable and long-lasting results. Depending on such individual peculiarities of each patient as his or her current age, health condition, and even lifestyle, they tend to last from a couple of months to half a year. Furthermore, these results might be substantially prolonged by periodical touch-up treatments.

It is also worth mentioning that the peculiarities of life each patient leads after Euflexxa injections have a strong impact on their results. For this reason, it is recommended to avoid strenuous exercise and heavy lifting for at least a week after the injection of the medication. This way, the safety and efficacy of the treatment will be maximized.


According to the researchers in the orthopedic sphere, adherence to after-treatment recommendations of a healthcare provider after undergoing a Euflexxa injection substantially improves its results (patients who follow the advice of their healthcare provider enjoy the efficacy of the medication in the target knee longer compared to those who ignore them).

What Success Rate Do Euflexxa Injections Have?

The success rate of Euflexxa is pretty high. While strongly depending on a number of factors (starting from the individual peculiarities of each patient and ending with his or her attentiveness to the recommendations of a healthcare provider), it looks as follows:

  • 50% of all patients are expected to experience substantial pain relief after undergoing the Euflexxa injection;
  • 30% of all patients are expected to enjoy full pain relief and absolute restoration of their knee function after the Euflexxa injection;
  • 20% of all patients are expected to experience little to no improvements compared to their initial condition (in these cases, a surgical intervention cannot be avoided to achieve pain relief).


In most cases, a healthcare provider will be unable to foresee the outcome of the Euflexxa injection with 100% accuracy. However, he or she might inform a patient of what to expect after running a detailed investigation of a patient’s current health condition.

Final Words

To sum up, an injection of Euflexxa is an effective way to get rid of osteoarthritis-related knee pain. Its high success rate makes it one of the most popular treatments to improve the overall condition of a patient who lives with the disease. Thus, how about trying out Euflexxa yourself and granting yourself an active lifestyle full of motion?